Pelosi, 82, has been the Democratic leader for two decades. She is expected to remain a member of the House, at least temporarily.
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Pelosi was speaker from 2007 to 2011 and returned to the top job in 2019.
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Pelosi said she will continue to represent her San Francisco district in the House.
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Pelosi, 82, is one of the most powerful lawmakers of her generation or any other, and her departure will rob Democrats of strategic acumen and unmatched fundraising skills.
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One of six children (and the only daughter), Nancy (Patricia D'Alesandro) Pelosi was born on March 26, 1940, and grew up in Baltimore's Little Italy
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Pelosi is the country’s first female speaker and has been in Congress for about 35 years.
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Departure triggers generational change in party leadership
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just weeks ago, her husband of nearly 60 years, Paul Pelosi, survived an assault by a hammer-wielding intruder at the family’s home in San Francisco.
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Pelosi to Exit as Top House Democrat, Ending Historic Era