Forward Malik Hall will be sidelined for the next three weeks due to a left foot stress reaction.
Despite Hall's outstanding performance so far, he began to feel pain after the game against Villanova on November 18.
The MSU men's basketball medical team said Hall picked up the injury and took a long time to recover from it before it turned into a more serious injury.
"I feel bad for Malik because he got off to a great start in the old season," head coach Tom Izzo said.
Another questionable player is second-year guard Jaden Akins, who also rehabbed a leg injury after the game against Villanova.
The Spartans will face conference opponents including Northwestern on Dec. 4 followed by Penn State on Dec. 7.
The Greens and Whites got off to a flying start, beating Kentucky and Villanova back-to-back to climb to 12th in the latest AP Top 25 poll.
MSU tips off tonight at 10:30 p.m. against Alabama at the Phil Knight Invitational. The starting schedule for the weekend and the next few weeks is being asked.