Christine wrote some of the band's most famous Grammy-winning songs, including "Little Lies," "Everywhere" and "Songbird," after joining them a few years after they broke up in 1967.
the Rock and Roll Hall of Fame in 1998, the band have sold over 100 million records worldwide and are considered one of the most successful bands of all time.
McVie's family said he died "peacefully" in hospital on Wednesday morning after a "short battle". Calling for privacy "during this painful time",
"everyone to keep Christine in their hearts and to remember the life of a great and respected musician"
Fleetwood Mac became one of the most popular bands of the 1970s and 1980s, and their famous names included Mick Fleetwood, Christine and her ex-husband John McVie, Lindsey Buckingham, and Stevie Nicks.
The 1977 album "Rumors" is considered one of the most successful albums of all time, selling over 40 million copies worldwide.
McVie left the group in 1998 but rejoined 16 years later for a long-term reunion.
In 2017, he revealed on BBC radio's 'Desert Island Discs' that he had left the world and developed agoraphobia after leaving the same band again and moving from California to Kent, North South East England.
In twitter, the group said: "There are no words to describe our sadness atthe death of Christine McVie. she was truly one of a kind, unique and talented individual.